Try not to stick in the same spot for too long - hammering the same piece of water is all well and good and yes, sometimes persistance will catch you fish, but in general your best chance of catching a fish (providing your flies are properly presented and working at the right depth) will be within your first couple of casts over it. As has already been mentioned grayling shoal tightly in the winter and can be hard to find, so keeping on the move is important, but once you hit a shoal you can do quite well.
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Also, even if it turns out there aren't any grayling about, both barbel and chub will take nymphs, so it's worth sticking at it