There is no best knot for all types of line. As an example the grinner knot used by hundreds of thousands of carp anglers throughout Europe is perfect for gel spun (HPPE) braided hook lengths.
However tie a four turn blood knot using the same gel spun and you will experience a substantial loss in breaking strain.
Dyneema and Spectra love grinner knots (Palomars as well) but hate bloods due to the strangulation effects of the knots construction. There can be a loss in strength of up to 50% between the two.
Fluorocarbon on the other hand breaks all the rules. Due to its different chemical make-up the much maligned blood knot untucked comes out head and shoulders above the normally trustworthy grinner.
I first bought fluorocarbon more than six years ago because of its sinking qualities and being slightly stiffer it would aid turnover. The claims of invisibility were not a deciding factor but if half true would do no harm.
I initially tied it choosing the grinner because having been a carp angler for many years had total confidence in it. When I tested it on some old but still accurate spring balance scales with a slow steady pull I was shocked to discover that the breaking strain did not reach half of the lines stated breaking strain.
Before I decided to bin it I tried other knots. What came as an even greater shock to the system was the performance of a simple four turn blood knot without the tuck. Carefully tied it reached 80% of the stated breaking strain. Since then for my general fly fishing for trout I have incurred very few losses using the old fashioned blood.
Be aware that there are many brands of fluorocarbon on sale that are not 100% pure fluoro, some are blended with nylon and are what can be loosely described as a type of alloy. If you are using 100% fluorocarbon my advice is to avoid the grinner or uni-knot like the plague.
The simple three turn water knot for droppers also works well with fluorocarbon and its extra stiffness helps reduce tangles.
Check out a more detailed and comprehensive article called ‘Ultimate Knots ‘on this sister sites Fishing Magic that explains why there is no best knot for all types of line.
Sorry I cannot do the link thing

but the piece is well worth reading and will open the eyes of a few.
Good luck and hope this helps,
Gotcha.