I used to use Danvilles Spiderweb for most of my river dries - still do.. on the rare occasions I tie any. You won't have that problem of snagging and fraying on your skin because it's single strand. Very easy to tie with... once you've got to grips with the breaking point. You need to fine tune the tension of your bobbin holder quite precisely, and then fine tune your handling of the stuff.
A regular and intensive manicure/skin care routine helps too

Buy yourself a footfile, and some hand cream. Blitz the rough stuff and moisturise everyday!

Yes, it's gay, but if you tie alot, it save alot of tears at the vice.