Very open ended question. At this time of year none if trout are your target lol.
Weighted nymphs (PTs, hares ears etc...) will catch a fair few grayling at the moment, atleast they are on the rivers I fish. Hatches are sporadic and short on our rivers at this time of year so, although I always have some dries with me, they are getting used less and less until next year.
Just take a selection of generic nymphs in a range of sizes and weights and you will be fine. I am definitely a believer that depth and presentation are more important than an exact replica of the fly. Especially when nymph fishing as their will be dozens of different nymph species present for the majority of the year so the trout and grayling will be used to seeing some variety. Weight is very important though, I take a range from unweighted to lead bombs and change depending on depth, flow and feeding habits of the fish. I would normally try a differnt weight before colour etc...
Dan
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